Adapalene è sicuro?
Independent skincare safety analysis · Updated April 05, 2026
48
Safety Concerns Noted
Significant safety concerns — consult a dermatologist before use
D
Adapalene has some safety concerns that warrant attention based on a Nerq Safety Score of 48.2/100 (D). Adapalene (INCI: Adapalene) is a cosmetic ingredient used as a synthetic retinoid for acne. Differin; now OTC 0.1%. More stable and less irritating than tretinoin. FDA-approved for acne.
Overall assessment: Adapalene is associated with safety concerns that require careful formulation review.
Queste informazioni sono solo a scopo educativo e non costituiscono consulenza medica. Consultare un professionista sanitario qualificato prima di prendere decisioni sulla salute.
Dettagli punteggio di sicurezza
Risultati principali sulla sicurezza
⚠Nerq Safety Score: 48.2/100 (Fair)
Regulatory Status of Adapalene
Regulatory data being compiled from FDA, EFSA, and WHO sources.
Data sourced from official regulatory databases. Always verify with the relevant authority for the most current status.
What are the safety concerns for Adapalene?
The primary area of concern is Overall (48/100). Perform a patch test before regular use.
Domande frequenti
Is Adapalene safe in skincare?
Adapalene has a Nerq Safety Score of 48.2/100 (D). Some Safety Concerns. Use with caution — consult a dermatologist.
Can Adapalene cause skin irritation?
Sensitization Risk score: 48/100. Irritation has been reported. Patch test before use.
Is Adapalene safe during pregnancy?
Consult your dermatologist or OB-GYN before using products containing Adapalene during pregnancy. Safety data may be limited for this use case.
Is Adapalene banned in the EU?
Regulatory Status score: 48/100. May have restrictions in some markets. Check EU CosIng database.
Is Adapalene comedogenic?
Comedogenicity depends on concentration and formulation. Check the product's full ingredient list and your skin type for the best assessment.
What are the side effects of Adapalene on skin?
Skin Safety score: 48/100. Side effects including irritation and sensitivity have been reported.
How does Adapalene compare to similar cosmetic ingredients?
Adapalene has a safety score of 48.2/100. Compare with similar ingredients below.
Similar Cosmetic Ingredients
Come abbiamo calcolato questo punteggio
Adapalene's safety score of 48.2/100 (D) is based on analysis of published toxicology data, regulatory filings, clinical studies, and adverse event reports. The score reflects 5 health-specific dimensions: Overall (48/100, ), Data Pending (48/100, ), Data Pending (48/100, ), Data Pending (48/100, ), Data Pending (48/100, ).
Nerq indexes over 7.5 million entities across 26 registries, enabling direct cross-category comparison. Scores are updated as new safety data becomes available.
Full methodology documentation · Machine-readable data (JSON API)
Last updated: April 05, 2026 · Data sources: FDA, EU-CosIng, EWG, SCCS, INCI
This page is for informational purposes only and does not constitute medical, nutritional, or dermatological advice.
Always consult a qualified professional before making health-related decisions.
Data sourced from FDA, EFSA, NIH, and peer-reviewed research.
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